Papillomavirus polypeptides E6 and E7 are zinc-binding proteins
Population
E6 and E7 polypeptides of human papillomavirus type 18 and bovine papillomavirus type 1
Comparison
Modified assay detecting zinc binding to… vs Well-characterized metalloproteins
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications for HPV management; leaves open zinc coordination as a research target for E6/E7 inhibition.
Structured PICO
P
Population
E6 and E7 polypeptides of human papillomavirus type 18 and bovine papillomavirus type 1
I
Intervention
Modified assay detecting zinc binding to proteins immobilized on filters under reducing conditions
C
Comparator
Well-characterized metalloproteins
O
Outcome
Zinc binding affinity and coordination mechanismsurrogate
Papillomavirus E6 and E7 proteins are identified as zinc-binding metalloproteins that likely coordinate zinc through cysteine residues.
Cite This Study
Barbosa et al. (1989) studied this question.