Angiopoietin-1 reduces VEGF-induced brain endothelial permeability via upregulation of ZO-2, highlighting a potential therapeutic mechanism for ischemia-induced vasogenic brain edema.
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Should not inform brain edema management; hypothesis-generating for Ang-1/ZO-2 targeting in ischemia models.
Seung Koo Lee (1998) studied this question.
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