Why the study?
Does switching to monovalent vaccine interrupt poliovirus transmission in areas with persistent transmission despite trivalent vaccine use?
Population
Populations in Uttar Pradesh and Bihar, India, with persistent poliovirus transmission despite high coverage…
Comparison
Switching to monovalent polio vaccine vs Trivalent polio vaccine
Design
Other
Authors
Loading...
Should not yet change polio vaccine policy in endemic areas; hypothesis-generating for monovalent formulations in high-density settings.
Does switching to monovalent vaccine interrupt poliovirus transmission in areas with persistent transmission despite trivalent vaccine use?
Switching from trivalent to monovalent polio vaccine may be necessary to eradicate polio in high-density, poor-sanitation areas of India.
Grassly et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: