What question did this study set out to answer?

To investigate whether the choroid plexus serves as an active cellular entry point and immunological mediator during central nervous system inflammation.

January 1, 2000Microscopy Research and TechniqueOpen Access

Involvement of the choroid plexus in central nervous system inflammation

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To investigate whether the choroid plexus serves as an active cellular entry point and immunological mediator during central nervous system inflammation.
Evaluated choroid plexus ultrastructure in an experimental autoimmune encephalomyelitis (EAE) model using electron microscopy.
Assessed adhesion molecule expression (ICAM-1, VCAM-1, and MAdCAM-1) in vivo via immunohistochemistry and in situ hybridization, as well as in cultured choroid plexus epithelial cells in vitro.
EAE induced marked ultrastructural alterations in the choroid plexus distinct from hypoxic changes, alongside polarized apical upregulation of ICAM-1 and VCAM-1 and de novo expression of MAdCAM-1 on epithelial cells.
Adhesion molecules were completely absent on fenestrated vascular endothelial cells, functionally mediated lymphocyte binding via known ligands, and were co-induced with MHC class I and II molecules in vitro.

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Implication

Experimental study reveals adhesion molecule upregulation in the choroid plexus during autoimmune encephalomyelitis, indicating an active gateway for central nervous system immunosurveillance.

Cite This Study

Engelhardt et al. (2000) studied this question.

synapsesocial.com/papers/6a7ccfbd72dd6fb91ccc0e0e https://doi.org/10.1002/1097-0029(20010101)52:1<112::aid-jemt13>3.0.co;2-5

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Implication

Experimental study reveals adhesion molecule upregulation in the choroid plexus during autoimmune encephalomyelitis, indicating an active gateway for central nervous system immunosurveillance.

Involvement of the choroid plexus in central nervous system inflammation

Key Points

Discussion

Implication

Cite This Study

Involvement of the choroid plexus in central nervous system inflammation

Key Points

Discussion

Implication

Cite This Study

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