Why the study?
Although creatine kinase is used for exertional rhabdomyolysis diagnosis, discrepancies exist between creatine kinase levels and clinical signs or symptoms.
Does strenuous physical exercise alter the urinary proteome profile in marine soldiers, and can these proteins serve as biomarkers for exertional rhabdomyolysis?
Population
10 marine soldiers in a special training course
Comparison
M1 (lowest creatine kinase levels) vs M2 (highest creatine kinase levels) during training
Design
Cohort study
Authors
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Urinary proteomics may identify ERM biomarkers beyond CK; leaves open clinical utility pending validation studies.
Does strenuous physical exercise alter the urinary proteome profile in marine soldiers, and can these proteins serve as biomarkers for exertional rhabdomyolysis?
A panel of six urinary proteins could serve as early, non-invasive biomarkers for exertional rhabdomyolysis during intense physical training.
Carneiro et al. (2022) studied this question.
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