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May 15, 2003New England Journal of Medicine

A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong

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Authors

NLNelson LeeDHDavid S.C. HuiAWAlan Wu

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Overview

Cohort study reports high rates of intensive care admission in patients with severe acute respiratory syndrome, identifying older age and elevated lactate dehydrogenase as adverse predictors.

Key Points

  • To characterize the clinical, laboratory, and radiologic features and identify predictors of adverse outcomes in patients presenting during a hospital outbreak of severe acute respiratory syndrome (SARS).
  • Analyzed demographic, laboratory, and radiologic findings for 138 patients with suspected SARS admitted to isolation wards at the Prince of Wales Hospital between March 11 and 25, 2003.
  • Evaluated clinical endpoints of intensive care unit admission and mortality using univariate and multivariate regression analyses.
  • Common presentations included fever (100%), chills (73.2%), lymphopenia (69.6%), thrombocytopenia (44.8%), and elevated lactate dehydrogenase (71.0%), with 23.2% (32/138) requiring intensive care admission and 3.6% (5/138) dying.
  • Multivariate analysis identified advanced age (OR per decade, 1.80; 95% CI, 1.16 to 2.81; P=0.009), high peak lactate dehydrogenase (OR per 100 U/L, 2.09; 95% CI, 1.28 to 3.42; P=0.003), and elevated initial neutrophil count (OR, 1.60; 95% CI, 1.03 to 2.50; P=0.04) as independent predictors of adverse outcome.

Cite This Study

Lee et al. (2003) studied this question.

synapsesocial.com/papers/6a7cd31f510816ccbf66e6d6https://doi.org/10.1056/nejmoa030685
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