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February 25, 2017British Journal of PharmacologyOpen Access

Chronic adiponectin treatment reduced body weight, total cholesterol, free fatty acids, and fasting glucose, and normalized NO-dependent vasorelaxation while decreasing PVAT inflammation compared with HFD rats.

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Why the study?

Does exogenous adiponectin improve endothelial function and metabolic parameters in Wistar rats fed a high-fat diet?

Population

Wistar rats fed a high-fat diet (and aged W12m rats)

Comparison

Exogenous adiponectin administered by continuous… vs High-fat diet rats without adiponectin treatment

Design

Preclinical

Follow-up

28 days

Authors

CSCristina M. SenaAPAna Marta PereiraRFRosa Fernandes

Discussion

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Overview

Adiponectin effects in obese rats are hypothesis-generating; leaves open translation to human endothelial dysfunction.

Structured PICO

Does exogenous adiponectin improve endothelial function and metabolic parameters in Wistar rats fed a high-fat diet?

P
Population
Wistar rats fed a high-fat diet (and aged W12m rats)
I
Intervention
Exogenous adiponectin administered by continuous subcutaneous infusion via minipump for 28 days
C
Comparator
High-fat diet (HFD) rats without adiponectin treatment
O
Outcome
Metabolism (body weight, total cholesterol, free fatty acids, fasting glucose, glucose tolerance), vascular reactivity (NO-dependent vasorelaxation, eNOS phosphorylation), and perivascular adipose tissue (PVAT) inflammationsurrogate

Exogenous adiponectin improves endothelial function and metabolic parameters in rats on a high-fat diet by increasing eNOS phosphorylation and reducing perivascular adipose tissue inflammation.

Cite This Study

Sena et al. (2017) studied this question.

synapsesocial.com/papers/6a7cd57d54044168e37bf386https://doi.org/10.1111/bph.13756
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