By injecting adjuvant into the tail rather than paw, valid bioassays were achieved in terms of paw volume and body growth after preventive treatment for 18 days, treatment of the established disease for 6 weeks, and 6 weeks after termination of 6 weeks of therapy. By these six criteria, and with doses of the fenamates (per kilogram) equivalent to human dosage, flufenamate was 2.6 to 5.6 and mefenamate 0.35 to 1.8 times as potent as phenylbutazone.
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Winder et al. (1969) studied this question.
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