Why the study?
Does CT or MRI accurately differentiate unilateral from bilateral adrenal abnormality compared to adrenal vein sampling in adults with primary aldosteronism?
Population
950 adults with primary aldosteronism from 38 studies
Comparison
Computed tomography or magnetic resonance imaging vs Adrenal vein sampling as the criterion standard
Design
Systematic_review
Authors
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High discordance cautions against CT/MRI-only lateralization in primary aldosteronism; challenges imaging-centric decisions and reinforces AVS as reference standard.
Does CT or MRI accurately differentiate unilateral from bilateral adrenal abnormality compared to adrenal vein sampling in adults with primary aldosteronism?
Relying solely on CT/MRI for lateralization in primary aldosteronism leads to misdiagnosis in nearly 40% of patients compared to AVS, potentially resulting in inappropriate surgical or medical management.
Marlies Kempers (2009) studied this question.
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