Why the study?
What are the histopathological differences in the atria between patients with long-term atrial fibrillation and those without arrhythmia?
Population
55 human hearts, including 12 with long-term atrial fibrillation and 43 controls with no arrhythmia.
Design
Case-control
Authors
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Supports atrial fibrosis as potential AF substrate; hypothesis-generating and should not yet change practice.
What are the histopathological differences in the atria between patients with long-term atrial fibrillation and those without arrhythmia?
Pathological lesions of the SA junction and atrial myocardium, characterized by severe fibrosis and lipomatosis, appear to be the main anatomic substratum for atrial fibrillation.
Ih et al. (1982) studied this question.
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