Determination of the Glycemic Threshold for the Regression or Prevention of Diabetic Microangiopathies, and the Insulin Injection Regimen to Establish Strict Glycemic Control in NIDDM.

Kawamoriand Kamada tion between ARC/IRCand the presence of nephropathy, neuropathy and retinopathy in the 4 groups were examined.Responses of aldosterone and its precursors, 1 1 -desoxycorticosterone (DOC), corticosterone (B) and 18-hydroxy-corticosterone(1 8-OH-B) to ACTHor angiotensin II (A II) were measured in normal subjects and in the 4 groups of diabetic patients in order to examineadrenal biosynthesis in this disorder.PRA in the diabetic patients was elevated to 2.4±2.2 from 0.8±0.6 ng/ml/h (3.2±1.7 from 1.2± 0.7 in normals) 2 h after furosemide (1 mg/kg) in an upright position.ARC was 15.8±3.3,9.0±3.0,13.7+2.2and 17.4±3.0pg/mlin diabetic groups I-IV, respectively (23.7±4.6 pg/ml in normals and 17.2 ± 3.9 pg/ml in chronic glomerulonephritis).On the other hand, IRC showed a high