What question did this study set out to answer?

To determine whether the endocytic receptor CD205 on cortical thymic epithelial cells is required for normal thymocyte development and positive T cell selection.

December 31, 2012PLoS ONEOpen Access

Normal T Cell Selection Occurs in CD205-Deficient Thymic Microenvironments

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To determine whether the endocytic receptor CD205 on cortical thymic epithelial cells is required for normal thymocyte development and positive T cell selection.
Evaluated polyclonal T cell development in a CD205-deficient thymic microenvironment.
Assessed monoclonal transgenic T cell receptor (TCR) development and selection in the absence of CD205.
CD205 deficiency did not alter or impede the progression of polyclonal T cell development.
Positive selection of monoclonal transgenic TCR T cells proceeded normally without an overt developmental defect in CD205-deficient settings.

Authors

WJWilliam E. JenkinsonNIHR Birmingham Biomedical Research Centre KNKyoko NakamuraFlorida International University AWAndrea J. WhiteNational Institutes of Health

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Implication

Experimental study demonstrates normal T cell development in CD205-deficient thymic environments, suggesting CD205 is dispensable for positive thymic selection.

Cite This Study

Jenkinson et al. (2012) studied this question.

synapsesocial.com/papers/6a7cdd8637b87b49edee24b5 https://doi.org/10.1371/journal.pone.0053416

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Implication

Experimental study demonstrates normal T cell development in CD205-deficient thymic environments, suggesting CD205 is dispensable for positive thymic selection.

Normal T Cell Selection Occurs in CD205-Deficient Thymic Microenvironments

Key Points

Discussion

Implication

Cite This Study

Normal T Cell Selection Occurs in CD205-Deficient Thymic Microenvironments

Key Points

Discussion

Implication

Cite This Study

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