Population
Platelets in plasma from humans, African Green and Rhesus monkeys, baboons, guinea pigs, rabbits, dogs…
Comparison
Thrombin receptor-derived activating peptides at… vs Human thrombin
Design
Preclinical
Authors
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Species variability in thrombin receptor peptide platelet responses cautions against extrapolating animal data to humans; leaves open optimal preclinical species selection.
Thrombin receptor-derived peptides exhibit significant species variability in their ability to induce platelet aggregation and other cellular responses, highlighting the need for careful species selection in preclinical thrombosis models.
Connolly et al. (1994) studied this question.
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