Why the study?
Does eprosartan improve blood pressure, proteinuria, and glomerulosclerosis in a rat model of reduced renal mass?
Population
Male Munich-Wistar rats with experimental renal disease induced by five-sixth nephrectomy
Comparison
Eprosartan administered for 4 weeks vs Vehicle treatment
Design
Preclinical
Follow-up
4 weeks
Authors
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Eprosartan effects in this rat model should not change practice; leaves open translation to human progressive renal disease.
Does eprosartan improve blood pressure, proteinuria, and glomerulosclerosis in a rat model of reduced renal mass?
In a rat model of reduced renal mass, eprosartan normalized blood pressure and reduced renal injury markers, suggesting potential utility in progressive renal disease.
Gandhi et al. (1999) studied this question.