August 1, 2002AJP Cell Physiology

Sarcoplasmic reticulum Ca²⁺ pump mRNA stability in cardiac and smooth muscle: role of the 3′-untranslated region

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Structured PICO

Population

Primary cultures of left ventricular muscle (LVM) cells and stomach smooth muscle (SSM) cells, and synthetic RNA corresponding to the 3'-untranslated region (UTR) of SERCA2a and -2b

Intervention

Inhibition of transcription and in vitro decay assays using nuclear and cytoplasmic extracts

Comparator

Comparison between LVM and SSM cells, and between SERCA2a and SERCA2b isoforms

Outcome

SERCA2 mRNA half-life and decay ratessurrogate

Nuclear decay of SERCA2 RNA, modulated by the 3'-UTR, is an initial step controlling its abundance, which may play a role in cardiac development and pathophysiology.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not inform clinical practice; hypothesis-generating for SERCA2 mRNA stability in cardiac development and pathophysiology.

Cite This Study

Misquitta et al. (2002) studied this question.

synapsesocial.com/papers/6a7cdf056d67ce102e8d1a83 https://doi.org/10.1152/ajpcell.00527.2001

View Full Paper

Ask AI

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Sarcoplasmic reticulum Ca²⁺ pump mRNA stability in cardiac and smooth muscle: role of the 3′-untranslated region

Structured PICO

Discussion

Implication

Cite This Study

Sarcoplasmic reticulum Ca²⁺ pump mRNA stability in cardiac and smooth muscle: role of the 3′-untranslated region

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider