What does this research mean for the field?

The human kidney expresses two alternatively spliced variants (HK1 and HK2) of the cardiac Ca2+-ATPase gene, producing proteins that are also present in other non-muscle tissues. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1988Journal of Biological ChemistryOpen Access

Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

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Population

Rabbit whole brain, cerebellum, liver, kidney, and COS-1 cell microsomes; human kidney cDNA library

Design

Preclinical

Authors

JLJonathan LyttonElectrophysiology DMDavid H. MacLennanElectrophysiology

Discussion

Member takes

Implication

Highlights Ca2+-ATPase diversity beyond muscle; leaves open functional roles of kidney splice variants in humans.

Structured PICO

Population

Rabbit whole brain, cerebellum, liver, kidney, and COS-1 cell microsomes; human kidney cDNA library

Intervention

Molecular cloning and immunological examination

Outcome

Identification and characterization of alternatively spliced products of the cardiac Ca2+-ATPase gene

The study identifies two alternatively spliced variants of the cardiac Ca2+-ATPase gene in human kidney, providing insights into the molecular diversity of calcium transport proteins in non-muscle tissues.

Cite This Study

Lytton et al. (1988) studied this question.

synapsesocial.com/papers/6a1892c3cac83a2bcecf7d32 https://doi.org/10.1016/s0021-9258(18)68141-4

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Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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