Key result
Molecular cloning from a rabbit uterine library revealed that the smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase is an alternatively spliced product of the cardiac/slow-twitch gene.
The study identifies the smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase as an alternatively spliced product of the cardiac/slow-twitch gene, serving as a ubiquitous 'housekeeping' isoform in non-muscle and smooth muscle tissues.
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Distinguishes SERCA isoforms by tissue; leaves open isoform-specific roles in human cardiovascular Ca2+ handling.
Lytton et al. (1989) studied this question. Molecular cloning and S1 nuclease mapping was evaluated on cDNA sequence and tissue-specific expression of Ca2+-ATPase isoforms. Molecular cloning from a rabbit uterine library revealed that the smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase is an alternatively spliced product of the cardiac/slow-twitch gene.
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