This basic science study demonstrates that smooth muscle expresses a distinct sarcoplasmic reticulum Ca2+-ATPase mRNA isoform that differs in its 3'-end sequence from the cardiac isoform.
Supports tissue-specific SERCA isoform diversity; leaves open functional consequences for vascular or cardiac Ca2+ handling.
We have investigated some characteristics of the sarcoplasmic reticulum (Ca2+ + Mg2+)-dependent ATPase (Ca2+-ATPase) mRNA from smooth muscle using specific cDNA probes isolated from a rat heart cDNA library. RNA blot analysis has shown that the Ca2+-ATPase mRNA expressed in smooth muscle is identical in size to the cardiac mRNA but differs from that of fast skeletal muscle. S1 nuclease mapping has moreover shown that the cardiac and smooth muscle isoforms possess different 3'-end sequences. These results indicate that a distinct sarcoplasmic reticulum Ca2+-ATPase mRNA is present in smooth muscle.
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Bastie et al. (1988) studied this question.
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