March 1, 1990Journal of Biological ChemistryOpen Access

Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene.

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Population

Rabbit genomic clones and myogenic cell line C2C12

Design

Preclinical

Authors

ÁZÁngel Zarain‐HerzbergUniversidad Nacional Autónoma de México DMD H MacLennanUniversity of Toronto MPMuthu PeriasamyHeart Failure & Transplant

Discussion

Member takes

Implication

Supports in vitro models of SERCA2 regulation; leaves open translation to human cardiac therapies.

Structured PICO

Population

Rabbit genomic clones and myogenic cell line C2C12

Intervention

Transfection with a plasmid containing the putative promoter and 946 bp upstream sequence of the SERCA2 gene coupled to the chloramphenicol acetyltransferase gene

Outcome

Transcriptional regulation and coordinate expression during terminal differentiation of myoblasts into myotubes

Identified the promoter and upstream sequence elements required for the regulated expression of the rabbit cardiac SERCA2 gene.

Cite This Study

Zarain‐Herzberg et al. (1990) studied this question.

synapsesocial.com/papers/6a8c7e22cb2a74952537997d https://doi.org/10.1016/s0021-9258(19)39615-2

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Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider