cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms.
Population
Rat aorta cDNA libraries, rat tissues (heart, brain, smooth muscles), and rat genomic DNA
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Supports alternative splicing for tissue-specific aortic calcium channel isoforms; leaves open relevance to human vascular disease.
Structured PICO
P
Population
Rat aorta cDNA libraries, rat tissues (heart, brain, smooth muscles), and rat genomic DNA
I
Intervention
cDNA cloning and sequencing of the alpha 1 subunit of the L-type dihydropyridine-sensitive voltage-dependent calcium channel (VDCC)
O
Outcome
Nucleotide sequence, deduced amino acid sequence, and identification of alternatively spliced formssurrogate
Cloning of the rat aorta L-type calcium channel reveals alternative splicing as a mechanism for generating tissue-specific isoforms.
Cite This Study
Koch et al. (1990) studied this question.