May 1, 1990Proceedings of the National Academy of SciencesOpen Access

Rat brain expresses a heterogeneous family of calcium channels.

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Population

Rat brain cDNAs and Xenopus oocytes injected with rat brain mRNA

Design

Preclinical

Authors

TSTerrance P. SnutchUniversity of British Columbia JLJ.P. LeonardUnited States Fish and Wildlife Service MGMary GilbertUniversity of British Columbia

Discussion

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Implication

Supports distinct neuronal Ca channel genes homologous to muscle isoforms; leaves open therapeutic targeting in brain or heart disorders.

Structured PICO

Population

Rat brain cDNAs and Xenopus oocytes injected with rat brain mRNA

Intervention

Antisense oligonucleotides against class A, B, and C Ca-channel cDNAs

Outcome

Expression of Ba current and voltage-gated Na or K conductancessurrogate

The study identifies multiple distinct voltage-gated calcium channel genes expressed in the rat brain, some of which are highly homologous to cardiac and skeletal muscle calcium channels.

Cite This Study

Snutch et al. (1990) studied this question.

synapsesocial.com/papers/6a83d46221c6da9699fe169a https://doi.org/10.1073/pnas.87.9.3391

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Rat brain expresses a heterogeneous family of calcium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rat brain expresses a heterogeneous family of calcium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider