October 1, 1997Circulation Research

Alternatively Spliced IS6 Segments of the α 1C Gene Determine the Tissue-Specific Dihydropyridine Sensitivity of Cardiac and Vascular Smooth Muscle L-Type Ca 2+ Channels

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Population

Preclinical models including functional expression of chimeras of alpha 1C-a and alpha 1C-b subunits, and…

Design

Preclinical

Authors

AWAndrea WellingTechnical University of Munich ALA. LudwigFriedrich-Alexander-Universität Erlangen-Nürnberg SZStephanie ZimmerPennsylvania State University

Discussion

Member takes

Implication

May enable vascular-selective dihydropyridines; leaves open human translation from this animal model.

Structured PICO

Population

Preclinical models including functional expression of chimeras of alpha 1C-a and alpha 1C-b subunits, and rat heart and aorta sections

Intervention

Dihydropyridines (nisoldipine)

Outcome

Dihydropyridine sensitivity and tissue-specific expression patterns of IS6 segmentssurrogate

The differential sensitivity of cardiac and vascular L-type Ca2+ channels to dihydropyridines is at least partially caused by tissue-specific expression of alternatively spliced IS6 segments of the alpha 1C gene.

Cite This Study

Welling et al. (1997) studied this question.

synapsesocial.com/papers/6a8d1cba0bd5a3045f314c73 https://doi.org/10.1161/01.res.81.4.526

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Alternatively Spliced IS6 Segments of the α 1C Gene Determine the Tissue-Specific Dihydropyridine Sensitivity of Cardiac and Vascular Smooth Muscle L-Type Ca 2+ Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alternatively Spliced IS6 Segments of the α 1C Gene Determine the Tissue-Specific Dihydropyridine Sensitivity of Cardiac and Vascular Smooth Muscle L-Type Ca 2+ Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider