Population
Seven alpha1C channel splice variants derived from the human alpha1C gene
Design
Preclinical
Authors
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May explain tissue-specific DHP responses; leaves open relevance to human dosing or variant-guided therapy.
Alternative splicing of the human alpha1C subunit gene significantly affects the sensitivity of L-type Ca2+ channels to the blocker isradipine, potentially explaining tissue-specific differences in drug response.
Zühlke et al. (1998) studied this question.
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