Key result
Transmembrane segment IIIS2 of the human alpha 1C subunit, regulated by alternative splicing, determines the sensitivity of Ca2+ channel splice variants to dihydropyridines.
Population
Xenopus oocytes expressing human alpha 1C subunit splice variants
Comparison
1,4-dihydropyridines and site-directed… vs Different splice variants / wild type vs mutated
Design
Preclinical
Authors
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May guide isoform-selective dihydropyridine design; leaves open clinical relevance of IIIS2 splicing in human disease.
Identifies the specific amino acids in the IIIS2 segment of the human L-type calcium channel alpha 1C subunit responsible for differential sensitivity to dihydropyridines.
Soldatov et al. (1995) studied this question. 1,4-dihydropyridines was evaluated on Voltage-dependent inhibition of Ca2+ channel splice variants. Transmembrane segment IIIS2 of the human alpha 1C subunit, regulated by alternative splicing, determines the sensitivity of Ca2+ channel splice variants to dihydropyridines.
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