Population
Recombinant RNA-dependent RNA polymerase of the bovine viral diarrhea virus and RNAs containing nucleotide…
Comparison
Nucleotide analogs with various modifications vs Unmodified nucleotides or different positions in…
Design
Preclinical
Authors
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May guide antiviral design against pestivirus polymerases; leaves open extension to human flaviviruses pending further validation.
The study defines specific functional group requirements on the initiation cytidylate for de novo RNA synthesis by the bovine viral diarrhea virus RNA-dependent RNA polymerase.
Kim et al. (2000) studied this question.
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