Paradoxical Embolism
Key result
Paradoxical embolism demands targeted diagnostics and secondary prevention strategies.
Population
Patients with venous thromboembolism in the presence of intracardiac or pulmonary shunts
Design
Review
Authors
Discussion
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Implication
This review provides an overview of the clinical manifestations, diagnostic tools, therapeutic options, and guideline recommendations for paradoxical embolism.
Key Points
- To review the diverse clinical presentations, diagnostic modalities for shunt detection, and current guideline-directed management strategies for paradoxical embolism.
- Synthesized clinical literature on the presentation and pathophysiology of paradoxical embolism arising from venous thromboembolism.
- Evaluated diagnostic modalities for detecting intracardiac and pulmonary shunts and summarized clinical guideline recommendations for secondary prevention.
- Identified paradoxical embolism as an under-recognized and under-reported clinical entity capable of causing life-threatening arterial ischemic events.
- Outlined noninvasive and invasive imaging approaches essential for identifying right-to-left intracardiac and intrapulmonary shunts.
- Summarized medical and catheter-based interventional options recommended by secondary prevention guidelines to reduce recurrent thromboembolic risk.
Structured PICO
P
Population
Patients with venous thromboembolism in the presence of intracardiac or pulmonary shunts
This review provides an overview of the clinical manifestations, diagnostic tools, therapeutic options, and guideline recommendations for paradoxical embolism.
Cite This Study
Windecker et al. (2014) conducted a review in Paradoxical embolism. Paradoxical embolism is a diverse, potentially life-threatening, and under-reported clinical entity requiring specific diagnostic tools and therapeutic strategies for secondary prevention.