Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC)
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Population
2,464 participants with chronic kidney disease without self-reported cardiovascular disease from the…
Design
Cross-sectional
Authors
Discussion
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Implication
hs-TnT nearly triples in eGFR <30 without overt CVD; warrants cautious interpretation and leaves open eGFR-adjusted thresholds.
Structured PICO
P
Population
2,464 participants with chronic kidney disease (eGFR 20-70 ml/min/1.73 m2) without self-reported cardiovascular disease from the multi-ethnic Chronic Renal Insufficiency Cohort (CRIC) in the United States, aged 21 to 74 years.
O
Outcome
High sensitivity cardiac troponin T (hs-TnT) levels and their renal and non-renal predictorssurrogate
In patients with chronic kidney disease without overt cardiovascular disease, lower eGFR, older age, male gender, black race, diabetes, and higher blood pressure are independently associated with higher levels of high sensitivity cardiac troponin T.
Limitations
- Subjects with known cardiovascular disease were excluded based on history, not left heart catheterization, so some with undetected coronary artery disease may have been included.
- Cross-sectional design cannot assume a causal relationship between factors associated with hs-TnT and incident CVD.
- Cannot separate the relative importance of hs-TnT production versus clearance as determinants of serum concentrations.
Cite This Study
Dubin et al. (2013) studied this question.
Topics
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