Why the study?
Reversion of diabetes and treatment of long-term obesity remain challenging, with rapid weight loss failures mainly related to lean mass wasting.
Does a personalized very low-calorie ketogenic diet (VLCKD) improve body composition and resting energy expenditure in subjects with Type 2 diabetes mellitus?
Does a personalized very low-calorie ketogenic diet (VLCKD) improve body composition and resting energy expenditure in subjects with Type 2 diabetes mellitus?
An 8-week personalized very low-calorie ketogenic diet may facilitate the short-term reversal of Type 2 diabetes while preserving lean mass and resting energy expenditure.
Answers are grounded in this paper and cite their sources.
Short-term VLCKD may aid T2D reversal while preserving lean mass; hypothesis-generating and requires randomized confirmation before practice change.
The reversion of diabetes and the treatment of long-term obesity are difficult challenges. The failure mechanisms of rapid weight loss are mainly related to the wasting of lean mass. This single-arm study aims to evaluate the effects of a very low-calorie ketogenic diet (VLCKD) on body composition and resting energy expenditure in the short term reversal of diabetes mellitus Type 2. For eight weeks, subjects were administered a personalized VLCKD with protein intake based on lean mass and synthetic amino acidic protein supplementation. Each subject was assessed by anthropometry, Dual-energy X-ray Absorptiometry(DXA), bioimpedentiometric analysis (BIA), indirect calorimetry, and biochemical analysis. The main findings were the saving of lean mass, the reduction of abdominal fat mass, restored metabolic flexibility, the maintenance of resting energy expenditure, and the reversion of diabetes. These results highlight how the application of preventive, predictive, personalized, and participative medicine to nutrition may be promising for the prevention of diabetes and enhancement of obesity treatment.
No takes yet. Share an insight, caveat, or question.
Romano et al. (2019) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: