Why the study?
The risk for metabolic disease increases with age, but mechanistic understanding of how age-induced alterations in plasma triglyceride metabolism contribute to metabolic disease remains limited.
Aging alters plasma triglyceride metabolism in humans and rodents, potentially contributing to age-associated metabolic diseases, highlighting the need for further mechanistic studies.
Age-related TG changes may elevate metabolic disease risk in older adults; leaves open targeted interventions pending prospective trials.
The risk for metabolic disease, including metabolic syndrome, insulin resistance, and diabetes, increases with age. Altered plasma TG metabolism and changes in fatty acid partitioning are also major contributors to metabolic disease. Plasma TG metabolism itself is altered by age in humans and rodents. As discussed in this review, the age-induced changes in human TG metabolism include increased plasma TG levels, reduced postprandial plasma TG clearance rates, reduced postheparin LPL activity, decreased adipose tissue lipolysis, and elevated ectopic fat deposition, all of which could potentially contribute to age-associated metabolic diseases. Similar observations have been made in aged rats. We highlight the limitations of currently available data and propose that mechanistic studies are needed to understand the extent to which age-induced alterations in TG metabolism contribute to metabolic disease. Such mechanistic insights could aid in therapeutic strategies for preventing or managing metabolic disease in older individuals.
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Spitler et al. (2020) studied this question.
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