Key result
Study assesses age effects on postheparin lipolytic activity without reporting specific results.
Why the study?
Does age affect postheparin lipolytic activity (PHLA) in elderly subjects?
Observational
Does age affect postheparin lipolytic activity (PHLA) in elderly subjects?
This study aimed to measure postheparin lipolytic activity in elderly subjects to understand the effect of age on triglyceride removal.
Absence of reported PHLA results leaves age effect on triglyceride clearance unresolved; further studies needed before clinical or mechanistic conclusions.
A HEPARIN-activated clearing factor, lipoprotein lipase, is considered to have an important role in facilitating the removal of triglycerides from the circulation. The activity of this enzyme is detectable in plasma by an in vitro assay and is commonly called postheparin lipolytic activity (PHLA).Aging has been associated with prolonged alimentary lipemia.1 2 There is also a positive correlation between fasting plasma triglyceride concentrations and age.3 , 4 To define further the effect of age on triglyceride removal, PHLA was measured in a group of elderly subjects.Methods and ResultsPHLA was measured by a modification of the method of Fredrickson, Ono and Davis . . .
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Brodows et al. (1972) conducted an observational in Aging. Age was evaluated on Postheparin lipolytic activity (PHLA). The effect of age on postheparin lipolytic activity was evaluated in elderly subjects, but specific results were not reported in the truncated abstract.
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