Key result
Adipose-tissue lipoprotein lipase activity has a negative correlation with serum triglyceride levels in human beings.
Postheparin plasma total lipolytic activity is composed of at least two triglyceride lipases, which play a role in the clearance of plasma triglycerides.
May link adipose LPL to TG clearance; leaves open whether this informs therapy or requires prospective trials.
A heterogeneous group of enzymes, including hepatic and extrahepatic lipases, monoglyceride hydrolase, and phospholipase, are released into plasma after heparin injection, and may function in clearance of plasma triglycerides, which are transported by chylomicrons and very-low-density lipoproteins.1 Hydrolysis of plasma triglycerides by lipoprotein lipase probably occurs in capillary endothelial cells and in the subendothelial spaces of adipose tissue.2 The relations of adipose-tissue lipoprotein lipase and hypertriglyceridemia in human beings have been assessed, with observation of a negative correlation between lipase activity and serum triglyceride levels.3 In postheparin plasma total lipolytic activity is composed of at least two triglyceride lipases, one . . .
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Charles J. Glueck (1975) conducted a review in Hypertriglyceridemia. Heparin injection was evaluated. Adipose-tissue lipoprotein lipase activity has a negative correlation with serum triglyceride levels in human beings.
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