June 1, 1999Experimental & Molecular MedicineOpen Access

Change of plasma lipoproteins by heparin-released lipoprotein lipase

View Full Paper

Ask AI

Bookmark

Why the study?

Does heparin injection alter plasma lipoprotein levels via lipoprotein lipase release in normo-lipidemic humans?

Population

13 normal healthy adults or patients with open heart surgery (normo-lipidemic subjects)

Comparison

Heparin 3 mg/kg body weight injection vs Baseline (pre-injection)

Design

Other

Follow-up

4 hours

Authors

JYJeong‐Yeh YangUniversity of Georgia TKTae-Keun KimElectronics and Telecommunications Research Institute BKBon-Sun KooJeonbuk National University

Discussion

Member takes

Implication

Heparin-released LPL may selectively lower VLDL-TG without affecting LDL/HDL in normolipidemics; leaves open clinical or therapeutic relevance.

Structured PICO

Does heparin injection alter plasma lipoprotein levels via lipoprotein lipase release in normo-lipidemic humans?

Population

13 normal healthy adults or patients with open heart surgery (normo-lipidemic subjects)

Intervention

Heparin 3 mg/kg body weight injection

Comparator

Baseline (pre-injection)

Outcome

Changes in blood lipid composition (triglyceride, total cholesterol) and levels of lipoproteins (VLDL, LDL, HDL) over 4 hourssurrogate

In normolipidemic humans, heparin-induced release of lipoprotein lipase primarily reduces VLDL triglycerides without significantly affecting cholesterol-rich lipoproteins (LDL and HDL).

Limitations

Only normo-lipidemic subjects were studied, limiting generalizability to hyperlipidemic or pathologic conditions

Cite This Study

Yang et al. (1999) studied this question.

synapsesocial.com/papers/6a9026296bfd95d7bd4dc9bc https://doi.org/10.1038/emm.1999.10

View Full Paper

Ask AI

Bookmark

June 1, 1999Experimental & Molecular MedicineOpen Access

Change of plasma lipoproteins by heparin-released lipoprotein lipase

View Full Paper

Ask AI

Bookmark

Why the study?

Does heparin injection alter plasma lipoprotein levels via lipoprotein lipase release in normo-lipidemic humans?

Population

13 normal healthy adults or patients with open heart surgery (normo-lipidemic subjects)

Comparison

Heparin 3 mg/kg body weight injection vs Baseline (pre-injection)

Design

Other

Follow-up

4 hours

Authors

JYJeong‐Yeh YangUniversity of Georgia TKTae-Keun KimElectronics and Telecommunications Research Institute BKBon-Sun KooJeonbuk National University

Discussion

Member takes

Implication

Heparin-released LPL may selectively lower VLDL-TG without affecting LDL/HDL in normolipidemics; leaves open clinical or therapeutic relevance.

Structured PICO

Does heparin injection alter plasma lipoprotein levels via lipoprotein lipase release in normo-lipidemic humans?

Population

13 normal healthy adults or patients with open heart surgery (normo-lipidemic subjects)

Intervention

Heparin 3 mg/kg body weight injection

Comparator

Baseline (pre-injection)

Outcome

Changes in blood lipid composition (triglyceride, total cholesterol) and levels of lipoproteins (VLDL, LDL, HDL) over 4 hourssurrogate

In normolipidemic humans, heparin-induced release of lipoprotein lipase primarily reduces VLDL triglycerides without significantly affecting cholesterol-rich lipoproteins (LDL and HDL).

Limitations

Only normo-lipidemic subjects were studied, limiting generalizability to hyperlipidemic or pathologic conditions

Cite This Study

Yang et al. (1999) studied this question.

synapsesocial.com/papers/6a9026296bfd95d7bd4dc9bc https://doi.org/10.1038/emm.1999.10

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark