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April 28, 2009Haemostasis

New Aspects on Heparin and Lipoprotein Metabolism

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Population

Rat organ perfusion models and general overview of lipoprotein metabolism

Comparison

Low molecular weight (LMW) heparin vs Conventional heparin

Design

Review

Authors

TOThomas OlivecronaGeneral / Preventive / LipidsGBGunilla Bengtsson-OlivecronaLouisiana State UniversityPØPer ØstergaardAalborg University

Discussion

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Implication

LMW heparin may lower circulating LPL activity versus conventional heparin; leaves open effects on lipid outcomes during anticoagulation.

Key Points

  • Review the structural roles of lipoprotein lipase and hepatic lipase in lipid metabolism and characterize how different heparin formulations affect enzyme release and clearance.
  • Summarized structural and physiological mechanisms of lipoprotein lipase (LPL) and hepatic lipase (HL) in plasma lipoprotein metabolism.
  • Utilized rat organ perfusion models to evaluate the release, hepatic uptake, and degradation kinetics of lipases under conventional heparin versus low molecular weight (LMW) heparin.
  • Conventional and LMW heparin exhibit similar efficacy in releasing lipases from extrahepatic tissue binding sites, but LMW heparin is less effective at preventing rapid hepatic uptake and degradation of LPL.
  • Heparin injection triggers a biphasic response: an initial acceleration of triglyceride-rich lipoprotein clearance driven by elevated circulating LPL, followed by a secondary phase of slowed metabolism attributed to endothelial LPL depletion.

Structured PICO

P
Population
Rat organ perfusion models and general overview of lipoprotein metabolism
I
Intervention
Low molecular weight (LMW) heparin
C
Comparator
Conventional heparin
O
Outcome
Lipoprotein lipase (LPL) activity, release, and hepatic degradationsurrogate

LMW heparin results in lower circulating LPL activity compared to conventional heparin because it is less effective at preventing LPL degradation by the liver.

Cite This Study

Olivecrona et al. (2009) studied this question.

synapsesocial.com/papers/6a7dc9fd75afeb5dc533969ahttps://doi.org/10.1159/000216924
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of heparin on the uptake of lipoprotein lipase in rat liver2004 · 31 citations
  2. 2Depletion of lipoprotein lipase after heparin administration.1993 · 35 citations
  3. 3Change of plasma lipoproteins by heparin-released lipoprotein lipase1999 · 20 citations
  4. 4Postheparin Lipoprotein Lipases1975 · 2 citations
  5. 5Interaction of Lipoprotein Lipase with Heparina1989 · 9 citations