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January 1, 2004Circulation JournalOpen Access

Troponin-T and Brain Natriuretic Peptide as Predictors for Adriamycin-Induced Cardiomyopathy in Rats

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Why the study?

Do ANP, BNP, and TnT predict doxorubicin-induced cardiomyopathy in a rat model?

Population

Male Wistar rats

Design

Preclinical

Follow-up

12 weeks

Authors

EKEikan KohKanazawa UniversityTNTsuneyuki NakamuraKanazawa UniversityHTHiroaki TakahashiMayo Clinic

Discussion

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Overview

May inform preclinical doxorubicin monitoring; leaves open translation to human cardiotoxicity prediction.

Structured PICO

Do ANP, BNP, and TnT predict doxorubicin-induced cardiomyopathy in a rat model?

P
Population
Male Wistar rats
I
Intervention
Doxorubicin (adriamycin) 2 mg/kg injected weekly via tail vein for 8 weeks
O
Outcome
Correlation between serum concentrations of ANP, BNP, and TnT and left ventricular % fractional shortening (%FS) at 6, 8, 10, and 12 weekssurrogate

Serum TnT and plasma BNP are useful early predictors of doxorubicin-induced cardiomyopathy in a rat model, with TnT elevation preceding functional decline.

Cite This Study

Koh et al. (2004) studied this question.

synapsesocial.com/papers/6a7cec5b5ea1f309fbcd8d9bhttps://doi.org/10.1253/circj.68.163
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Also Consider

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  1. 1Clinical Significance of Blood Brain Natriuretic Peptide Level Measurement in the Detection of Heart Disease in Untreated Outpatients2002 · 32 citations
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  5. 5Natriuretic peptides during the development of doxorubicin‐induced left ventricular diastolic dysfunction2002 · 118 citations