What question did this study set out to answer?

To examine long-term survival outcomes and prognostic factors in adults experiencing disease recurrence after treatment for acute lymphoblastic leukemia.

October 10, 2006BloodOpen Access

Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study

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Authors

AFAdele K. FieldingNew York Blood Center SRSusan RichardsAVEO Oncology (United States)RCRajesh ChopraVardhman Mahavir Medical College & Safdarjung Hospital

Discussion

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Implication

Cohort study finds poor post-relapse survival in adults with acute lymphoblastic leukemia, highlighting the necessity of preventing disease recurrence.

Key Points

To examine long-term survival outcomes and prognostic factors in adults experiencing disease recurrence after treatment for acute lymphoblastic leukemia.
Analyzed clinical follow-up data from 609 adults with recurrent acute lymphoblastic leukemia previously enrolled in the MRC UKALL12/ECOG 2993 trial.
Evaluated 5-year overall survival following relapse and assessed prognostic variables including age, duration of first complete remission, and prior therapies.
Five-year overall survival was 7% (95% CI, 4%–9%) following relapse, compared to 38% (95% CI, 36%–41%) for newly diagnosed patients.
Younger age predicted improved post-relapse survival (5-year OS 12% for age <20 years vs. 3% for age >50 years; 2P < .001).
Longer duration of first complete remission (>2 years) conferred superior 5-year survival compared to shorter remission (<2 years) (11% vs. 5%; 2P < .001), whereas initial remission treatment did not alter salvage outcomes.

Cite This Study

Fielding et al. (2006) studied this question.

synapsesocial.com/papers/6a7cec965ea1f309fbcd8daa https://doi.org/10.1182/blood-2006-05-018192

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Implication

Cohort study finds poor post-relapse survival in adults with acute lymphoblastic leukemia, highlighting the necessity of preventing disease recurrence.

Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study

Discussion

Member takes

Implication

Key Points

Cite This Study

Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study

Discussion

Member takes

Implication

Key Points

Cite This Study

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