Why the study?
Does olmesartan reduce blood pressure and improve cardiovascular remodeling via ACE2 over-expression in stroke-prone spontaneously hypertensive rats?
Population
12-week-old stroke-prone spontaneously hypertensive rats (SHRSP)
Comparison
Olmesartan 0.5 mg/kg/day for 4 weeks, with or… vs Vehicle
Design
Preclinical
Follow-up
4 weeks
Authors
Loading...
Raises Ang II with Ang-(1-7) antagonism plus ARB; leaves open net remodeling effects in hypertensive rat models.
Does olmesartan reduce blood pressure and improve cardiovascular remodeling via ACE2 over-expression in stroke-prone spontaneously hypertensive rats?
Olmesartan may protect against cardiovascular remodeling and reduce Ang II levels by increasing cardiac nitric oxide production and endogenous Ang-(1-7) via ACE2 over-expression.
Agata et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: