Why the study?
In patients with PH, anesthetic management requires minimizing RV load and preventing abrupt changes in PVR.
Does remimazolam provide stable hemodynamics and safe perioperative care in a patient with pulmonary hypertension and right ventricular failure undergoing percutaneous left atrial appendage closure?
Does remimazolam provide stable hemodynamics and safe perioperative care in a patient with pulmonary hypertension and right ventricular failure undergoing percutaneous left atrial appendage closure?
Remimazolam may be a safe and effective anesthetic agent for maintaining hemodynamic stability in patients with pulmonary hypertension and right ventricular failure undergoing percutaneous interventions.
Remimazolam may enable stable anesthesia in PH without collapse; hypothesis-generating and should not yet change practice.
In the anesthetic management of patients with pulmonary hypertension (PH), it is essential to minimize right ventricular (RV) load and prevent abrupt changes in pulmonary vascular resistance (PVR). We report a case in which safe anesthetic management was achieved without circulatory collapse by using remimazolam in a patient with PH. An 84-year-old woman was scheduled to undergo percutaneous left atrial appendage closure for non-valvular atrial fibrillation. She had developed secondary PH and RV failure secondary to atrial fibrillation and systemic sclerosis, necessitating careful general anesthesia with positive pressure ventilation. Total intravenous anesthesia was administered using remifentanil and remimazolam. Hemodynamic stability was maintained throughout induction and intraoperative management. Transesophageal echocardiography performed during the procedure revealed no exacerbation of PH or RV failure, and the percutaneous catheter procedure was completed uneventfully. The patient's postoperative course was also uneventful, and she was discharged without any serious complications. Anesthesia management using remimazolam might be beneficial in patients with PH, as it provides stable hemodynamics and allows for safe perioperative care.
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Ryo et al. (2025) studied this question.
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