July 19, 2012CirculationOpen Access

MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway

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Why the study?

Does overexpression of miR-101a reduce interstitial fibrosis and improve cardiac performance in a rat model of chronic myocardial infarction?

Population

Rats with chronic myocardial infarction induced by coronary artery ligation, and cultured rat neonatal…

Design

Preclinical

Follow-up

4 weeks

Authors

ZPZhenwei PanElectrophysiology XSXuelin SunChinese Academy of Medical Sciences & Peking Union Medical College HSHongli ShanShanghai University

Discussion

Member takes

Implication

Hypothesis-generating for miR-101a modulation post-MI; prospective studies required before clinical translation.

Structured PICO

Does overexpression of miR-101a reduce interstitial fibrosis and improve cardiac performance in a rat model of chronic myocardial infarction?

Population

Rats with chronic myocardial infarction induced by coronary artery ligation, and cultured rat neonatal cardiac fibroblasts.

Intervention

Adenovirus-mediated overexpression of miR-101a (in vivo) and forced expression of miR-101a/b (in vitro).

Outcome

Cardiac performance (echocardiography and hemodynamic measurements) and interstitial fibrosis at 4 weeks.surrogate

Overexpression of miR-101a mitigates interstitial fibrosis and improves cardiac performance in a rat model of chronic myocardial infarction via the c-Fos/TGF-β1 pathway.

Cite This Study

Pan et al. (2012) studied this question.

synapsesocial.com/papers/6a7cefa28fc303b9e22fa7d0 https://doi.org/10.1161/circulationaha.112.094524

Topics

Echocardiography

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MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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