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August 1, 1995Development

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

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Authors

KMKenji MatsunoOsaka University of EconomicsRDR J DiederichHoward Hughes Medical InstituteMGMasahiro J. GoFoundation for Biomedical Research and Innovation

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Implication

Molecular and genetic analysis reveals Deltex activates Notch signaling by binding ankyrin repeats, suggesting it prevents cytoplasmic retention of Suppressor of Hairless.

Key Points

  • To elucidate the molecular and genetic mechanisms by which Deltex regulates Notch pathway activity through domain-specific physical interactions.
  • Mapped heterotypic Deltex-Notch intracellular domain interactions and Deltex homotypic interactions using a yeast interaction trap assay.
  • Evaluated the functional role of Deltex interaction domains and the subcellular localization of Suppressor of Hairless using in vivo expression systems and cell culture assays.
  • Deltex physically binds to the ankyrin repeat region of the Notch intracellular domain and also engages in homotypic interactions.
  • Deltex-Notch binding prevents the cytoplasmic sequestration of Suppressor of Hairless by Notch ankyrin repeats, promoting signaling activation.

Cite This Study

Matsuno et al. (1995) studied this question.

synapsesocial.com/papers/6a7cf6443d640844b95e040ehttps://doi.org/10.1242/dev.121.8.2633
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.1991 · 127 citations
  2. 2The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells.1992 · 133 citations
  3. 3Antagonistic activities of <i>Suppressor of Hairless</i> and <i>Hairless</i> control alternative cell fates in the <i>Drosophila</i> adult epidermis1994 · 145 citations