What question did this study set out to answer?

To examine the relationship between localized skeletal muscle contraction and both local and remote upstream arteriolar dilations and determine the pathway of signal transmission.

November 1, 2000AJP Heart and Circulatory Physiology

Local and remote arteriolar dilations initiated by skeletal muscle contraction

View Full Paper

Ask AI

Bookmark

Population

Anesthetized hamsters (cremaster muscle model)

Comparison

Microelectrode stimulation of 4-5 muscle fibers… vs Baseline (before stimulation)

Design

Preclinical

Authors

CMCoral L. MurrantUniversity of Guelph ISIngrid H. SareliusUniversity of Rochester

Discussion

Member takes

Implication

Remote dilation from contraction persists independently of neural/gap-junction blockade; leaves open the transmitting signal in microvascular physiology.

Key Points

To examine the relationship between localized skeletal muscle contraction and both local and remote upstream arteriolar dilations and determine the pathway of signal transmission.
Microelectrodes stimulated 4–5 muscle fibers overlapping a transverse arteriole in the cremaster muscle of anesthetized hamsters at 2, 4, or 8 Hz for 2 minutes.
Arteriolar diameters were measured at the local site of muscle overlap and at a remote site approximately 1,000 µm upstream before, during, and after contraction.
Transmission mechanisms were tested by applying tetrodotoxin (2 µM), halothane (0.07%), or 18-beta-glycyrrhetinic acid (40 µM) between the local and upstream sites.
Two minutes of stimulation at 2, 4, and 8 Hz dilated local arterioles by 8.2 ± 2.0 µm, 22.5 ± 2.4 µm, and 30.9 ± 2.1 µm, respectively.
Remote upstream arterioles dilated by 4.2 ± 0.8 µm, 11.0 ± 1.1 µm, and 18.9 ± 2.7 µm during 2-, 4-, and 8-Hz stimulation, respectively.
Remote dilation during 4-Hz contraction was not blocked by 15-minute micropipette application of tetrodotoxin, halothane, or 18-beta-glycyrrhetinic acid.

Structured PICO

Population

Anesthetized hamsters (cremaster muscle model)

Intervention

Microelectrode stimulation of 4-5 muscle fibers (2, 4, or 8 Hz for 2 minutes) with or without application of tetrodotoxin, halothane, or 18-beta-glycyrrhetinic acid

Comparator

Baseline (before stimulation)

Outcome

Diameter of the arteriole at the site of muscle fiber overlap (local) and at a remote site approximately 1,000 microm upstreamsurrogate

Muscle contraction initiates a robust remote arteriolar dilation that does not appear to be transmitted via perivascular nerves or gap junctions.

Cite This Study

Murrant et al. (2000) studied this question.

synapsesocial.com/papers/6a7cf7d3e83b38d3217bf970 https://doi.org/10.1152/ajpheart.2000.279.5.h2285

View Full Paper

Ask AI

Bookmark

Implication

Remote dilation from contraction persists independently of neural/gap-junction blockade; leaves open the transmitting signal in microvascular physiology.

Local and remote arteriolar dilations initiated by skeletal muscle contraction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Local and remote arteriolar dilations initiated by skeletal muscle contraction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider