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May 28, 2007

Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study.

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Why the study?

Does a simple clinical model accurately predict the 7-year risk of incident type 2 diabetes mellitus in middle-aged adults compared to complex biomarker models?

Population

Middle-aged white adults who had an oral glucose tolerance test at baseline (160 cases of new T2DM).

Comparison

Simple clinical prediction model. vs Personal model and complex clinical models.

Design

Cohort

Follow-up

7 years

Authors

PWPeter W.F. Wilson

Discussion

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Overview

Simple models suffice for 7-year T2DM risk discrimination in middle-aged adults; leaves open prospective validation before practice change.

Structured PICO

Does a simple clinical model accurately predict the 7-year risk of incident type 2 diabetes mellitus in middle-aged adults compared to complex biomarker models?

P
Population
Middle-aged white adults who had an oral glucose tolerance test at baseline (160 cases of new T2DM).
I
Intervention
Simple clinical prediction model (parental history of diabetes, obesity, hypertension, low HDL cholesterol, elevated triglycerides, and impaired fasting glucose).
C
Comparator
Personal model (age, sex, parental history, BMI) and complex clinical models (adding 2-hour post-OGTT glucose, fasting insulin, CRP, Gutt index, HOMA-IR, HOMA-beta).
O
Outcome
Incident type 2 diabetes mellitus at 7 years.hard clinical

A simple clinical model using routine measurements effectively predicts the 7-year risk of type 2 diabetes, with no added benefit from complex biomarkers.

Cite This Study

Peter W.F. Wilson (2007) studied this question.

synapsesocial.com/papers/6a7cf8f96e07fdc915aeb65bhttps://doi.org/10.1001/archinte.167.10.1068
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Also Consider

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