December 1, 2019MedicineOpen Access

The effect of Chinese herbal medicine combined with western medicine on vascular endothelial function for patients with hypertension

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Why the study?

Traditional Chinese medicine combined with western medicine can improve vascular endothelial function in hypertension, but its efficacy and safety in essential hypertension have not been systematically evaluated.

Does Chinese herbal medicine combined with western medicine improve blood pressure and vascular endothelial function in patients with essential hypertension?

Population

Patients with essential hypertension

Comparison

TCM combined with western medicine vs western medicine

Design

Systematic review and meta-analysis protocol of randomized controlled trials

Authors

WRWeiquan Ren JLJiangquan LiaoChina-Japan Friendship Hospital JCJialiang ChenGaozhou People's Hospital

Discussion

Member takes

Implication

Supports TCM adjunct to western medicine for endothelial dysfunction in hypertension; extends trial data via first systematic synthesis.

Structured PICO

Does Chinese herbal medicine combined with western medicine improve blood pressure and vascular endothelial function in patients with essential hypertension?

Population

Patients aged 18 to 80 years with essential hypertension (SBP ≥140 mm Hg or DBP ≥90 mm Hg). Excluded: serious cardiovascular diseases, hepatic failure, renal failure, secondary hypertension, gestational hypertension, and isolated systolic hypertension.

Intervention

Chinese herbal medicine (CHM) combined with western medicine

Comparator

Western medicine alone

Outcome

Changes in blood pressure (SBP, DBP, 24 hour SBP, 24 hour DBP) and endothelial function markers (nitric oxide, endothelin-1, flow-mediated dilation, vascular endothelial growth factor, high-sensitive C-reactive protein, angiotensin II, von Willebrand factor, and transforming growth factor b-1)surrogate

This protocol outlines a systematic review and meta-analysis to evaluate the efficacy and safety of combining Chinese herbal medicine with western medicine for improving vascular endothelial function in essential hypertension.

Limitations

Heterogeneity risks due to different doses, age, and severity of hypertension
Small sample sizes may lead to a high risk of bias

Cite This Study

Ren et al. (2019) studied this question.

synapsesocial.com/papers/6a7cf91f5b398ef9349295bd https://doi.org/10.1097/md.0000000000018134

View Full Paper

Ask AI

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The effect of Chinese herbal medicine combined with western medicine on vascular endothelial function for patients with hypertension

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The effect of Chinese herbal medicine combined with western medicine on vascular endothelial function for patients with hypertension

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider