Why the study?
A dose-response meta-analysis of the relationship between physical activity and the risk of depression had never been conducted.
Does leisure-time physical activity reduce the risk of incident depression in healthy individuals?
Comparison
Different doses of leisure-time physical activity vs the lowest category
Design
Dose-response meta-analysis of prospective cohort studies
Authors
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Supports inverse dose-response of LTPA with depression risk; hypothesis-generating, RCTs needed before practice change.
Does leisure-time physical activity reduce the risk of incident depression in healthy individuals?
There is a nonlinear U-shaped relationship between leisure-time physical activity and incident depression, where moderate doses (<25 MET-h/week) are protective but higher doses may increase risk.
Guo et al. (2022) studied this question.
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