October 7, 2015MoleculesOpen Access

Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events

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Population

Mice (pulmonary thromboembolism model induced by collagen and epinephrine) and in vitro platelets

Design

Preclinical

Authors

Discussion

Supports preclinical antithrombotic development of benzofuroxan derivatives; hypothesis-generating for human translation.

Population

Mice (pulmonary thromboembolism model induced by collagen and epinephrine) and in vitro platelets

Intervention

N-oxide derivatives (furoxan and benzofuroxan compounds)

Outcome

Inhibition of platelet aggregation and protection from pulmonary thromboembolismsurrogate

N-oxide derivative 14a represents a promising new antiplatelet and antithrombotic prototype for the prevention of atherothrombotic events.

Rosseto et al. (2015) studied this question.

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