Why the study?
Does flecainide alter exercise hemodynamics and electrocardiography in patients with paroxysmal supraventricular tachyarrhythmias without structural heart disease?
Population
n=24 patients with paroxysmal supraventricular tachyarrhythmias, normal cardiac structure, and normal sinus…
Comparison
Flecainide 200 mg/day for 1 week vs Placebo for 1 week
Design
RCT, randomized, double-blind
Follow-up
1 week
Authors
Loading...
Flecainide blunts exercise heart rate and widens QRS; extends RCT evidence on its electrophysiologic effects in paroxysmal SVT without structural heart disease.
Does flecainide alter exercise hemodynamics and electrocardiography in patients with paroxysmal supraventricular tachyarrhythmias without structural heart disease?
In patients without structural heart disease, flecainide alters exercise electrophysiology by depressing sinus node automaticity, slowing ventricular conduction, and accelerating ventricular repolarization.
Lau et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: