August 22, 2014Molecular CancerOpen Access

Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma

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Why the study?

Does ANGPTL4 overexpression inhibit tumor growth, angiogenesis, and metastasis in hepatocellular carcinoma?

Structured PICO

Does ANGPTL4 overexpression inhibit tumor growth, angiogenesis, and metastasis in hepatocellular carcinoma?

Population

Hepatocellular carcinoma (HCC) patients (tumor and non-tumor liver tissues) and orthotopic liver tumor nude mice model using a human metastatic cell line

Intervention

ANGPTL4-overexpressing adenovirus (Ad-ANGPTL4) injected via portal vein; recombinant ANGPTL4 protein

Comparator

Non-tumor liver tissues (for human samples); control (implied for mice)

Outcome

Tumor growth, invasiveness, metastasis, and ANGPTL4 mRNA levelssurrogate

ANGPTL4 acts as a diagnostic and prognostic biomarker and a potential therapeutic agent to suppress HCC growth and metastasis.

Discussion

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Implication

ANGPTL4 overexpression may inhibit HCC progression in models; leaves open therapeutic translation pending human trials.

Cite This Study

Ng et al. (2014) studied this question.

synapsesocial.com/papers/6a7cfb0d43e32f7085a56790 https://doi.org/10.1186/1476-4598-13-196

View Full Paper

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Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma

Structured PICO

Discussion

Implication

Cite This Study

Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma

Structured PICO

Discussion

Implication

Cite This Study

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