What question did this study set out to answer?

To review the relationship between human papillomavirus infection and cervical cancer, focusing on viral pathogenesis, immune mechanisms, diagnostic approaches, and preventative strategies.

April 30, 2025Modern Care JournalOpen Access

Human Papillomavirus and Cervical Cancer: A Narrative Review

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To review the relationship between human papillomavirus infection and cervical cancer, focusing on viral pathogenesis, immune mechanisms, diagnostic approaches, and preventative strategies.
Searched PubMed, Scopus, Web of Science, and Google Scholar for literature published through 2024 without start-date restrictions.
Synthesized evidence from clinical studies, narrative reviews, systematic reviews, and meta-analyses using search terms including HPV pathogenesis, immune response, cervical cancer, diagnostics, and prevention.
Persistent infection with high-risk genotypes, predominantly HPV-16 and HPV-18, induces chronic inflammation and drives the progression of precancerous lesions to invasive cervical cancer.
Comprehensive prevention paradigms incorporating prophylactic HPV vaccination, regular Pap smear screening, and sensitive biomarker assays substantially reduce cervical cancer incidence and disease-related mortality.

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Implication

Narrative review demonstrates persistent high-risk human papillomavirus infection drives cervical carcinogenesis, highlighting the vital impact of early screening and vaccination programs.

Cite This Study

Jafari-Sales et al. (2025) studied this question.

synapsesocial.com/papers/6a7cfb39a3387a3e88ec2451 https://doi.org/10.5812/mcj-159690

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Implication

Narrative review demonstrates persistent high-risk human papillomavirus infection drives cervical carcinogenesis, highlighting the vital impact of early screening and vaccination programs.

Human Papillomavirus and Cervical Cancer: A Narrative Review

Key Points

Discussion

Implication

Cite This Study

Human Papillomavirus and Cervical Cancer: A Narrative Review

Key Points

Discussion

Implication

Cite This Study

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