January 1, 2009Circulation JournalOpen Access

Pioglitazone Reduces the Necrotic-Core Component in Coronary Plaque in Association With Enhanced Plasma Adiponectin in Patients With Type 2 Diabetes Mellitus

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Why the study?

Does pioglitazone improve coronary plaque composition and plasma adiponectin levels in patients with type 2 diabetes mellitus and stable angina pectoris?

Population

54 patients with type 2 diabetes mellitus and stable angina pectoris, scheduled for percutaneous coronary…

Comparison

Pioglitazone 15 mg/day added to existing… vs Continued previous antidiabetic regimen.

Design

RCT, Randomly assigned to the pioglitazone group or the control group., Open…

Follow-up

6 months

Authors

DODaisuke OgasawaraScripps Research Institute JSJunya ShiteSaiseikai Nakatsu Hospital TSToshiro ShinkeInterventional Cardiology

Discussion

Member takes

Implication

Pioglitazone may stabilize plaques in T2DM patients with stable angina; extends evidence on adiponectin-mediated necrotic-core reduction.

Structured PICO

Does pioglitazone improve coronary plaque composition and plasma adiponectin levels in patients with type 2 diabetes mellitus and stable angina pectoris?

Population

54 patients with type 2 diabetes mellitus and stable angina pectoris, scheduled for percutaneous coronary intervention (PCI) and 6-month follow-up angiography. Excluded: significant hepatic or renal disease, congestive heart failure (NYHA class II-IV), or systemic inflammatory disorders.

Intervention

Pioglitazone 15 mg/day added to existing medications for diabetes mellitus for 6 months.

Comparator

Continued previous antidiabetic regimen (control group).

Outcome

Change in plasma adiponectin levels and the change in each VH-IVUS parameter from baseline to 6-month follow-up.surrogate

Pioglitazone may stabilize coronary plaques in patients with type 2 diabetes by reducing the necrotic-core component, which correlates with increased plasma adiponectin levels.

Limitations

VH-IVUS is only a substitute for histopathologic sampling and dividing plaque into 4 distinct tissue components is difficult because of amorphous overlapping zones.
Potential limitations for the classification of Dense-calcium by VH-IVUS analysis due to acoustic shadow.
Only examined PCI-related vessels and analyzed merely non-culprit, moderate obstructive lesions, which may not be representative of the whole coronary artery.

Cite This Study

Ogasawara et al. (2009) studied this question.

synapsesocial.com/papers/6a7cfb5e5b398ef9349296ec https://doi.org/10.1253/circj.cj-08-0699

Topics

Coronary artery disease Coronary CT angiography

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Pioglitazone Reduces the Necrotic-Core Component in Coronary Plaque in Association With Enhanced Plasma Adiponectin in Patients With Type 2 Diabetes Mellitus

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Pioglitazone Reduces the Necrotic-Core Component in Coronary Plaque in Association With Enhanced Plasma Adiponectin in Patients With Type 2 Diabetes Mellitus

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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Topics

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