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August 31, 2021Science SignalingOpen Access

Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption

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Design

In vitro and in vivo preclinical study

Authors

CRCara C. RadaStanford UniversityHMHilda Mejia-PenaNGNeil GrimseyGeorgia College & State University

Discussion

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Implication

Hypothesis-generating for HSP27 in vascular permeability; prospective studies needed before any clinical consideration.

Structured PICO

P
Population
in vitro endothelial cells and in vivo models
I
Intervention
small-molecule inhibitor J2 or phosphorylation-deficient mutant of HSP27
O
Outcome
endothelial barrier permeability in vitro and vascular leakage in vivosurrogate

HSP27 phosphorylation and oligomer dynamics, regulated by the p38-MK2-MK3 signaling axis, are critical for endothelial barrier recovery and preventing vascular leakage.

Cite This Study

Rada et al. (2021) studied this question.

synapsesocial.com/papers/6a7d0179ade38b7dc346c862https://doi.org/10.1126/scisignal.abc1044
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