An Association Between Thyroid Function Status and Bone Mineral Density (Bmd) Among Postmenopausal Women With Osteoporosis

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BACKGROUND is the most common metabolic bone disorder. It is a disorder characterized by low bone and micro architectural of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. Thyroid hormones necessary to normal development and function of human skeleton. aim of this study was to investigate the association between thyroid function status and mineral density (BMD) among women with osteoporosis. AND METHODS study was completed in central diagnostic biochemistry laboratory, medical college, Thiruvananthapuram. Consecutive samples (5 ml) were collected from the postmenopausal women after confirming menopause, attending camp under the of orthopaedic department, MCH hospital, to detect Bone mineral density by quantitative ultra sonometry. and the parameters evaluating are Serum T3, T4, TSH, Serum Calcium, Phosphorous and ALP, in the Central Biochemistry Laboratory, Medical College Hospital, Thiruvananthapuram. TSH of osteoporosis 1.61 ± 1.24, that of control 3.38 ± 1.65, p value is <0.001. There is a positive correlation BMD and TSH, p value is Significant (<0.001) and r value (0.565). Average T4 of osteoporosis (10.54 ± 1.70), that control (9.98 ± 1.67). and average T3 of osteoporosis (1.23 ± 0.25), that of control 1.13 ± 0.16. p value is >0.05. T3 and 4 shows No correlation with bone mineral density. osteoporosis population 83.3% of individuals having TSH value in the lower range of normal value. The study concluded that is a positive correlation with Bone mineral density and TSH, even at TSH level with in the normal limit. The p value is< 0.001 and the coefficient of correlation r = 0.565 Similarly, the study also concluded that there is no correlation of mineral density with T3 and T4. The mean serum levels of T3 and T4 were similar among women with or without . The low-normal TSH levels were associated with lowered BMD value. Average TSH of osteoporosis is 1.61 ± 1.24, of control 3.38 ± 1.65, p value is <0.001